Senior Scientist

  • Full Time (PhD/MD)
  • Newton, MA

Stealth-Mode mRNA Engineering Company

We’re a VC/angel-backed, stealth-mode RNA platform company melding new bioE tools, computation, and deep mRNA know-how to establish a systematic method to transform standard of care for neglected diseases.

What You Will Achieve

  • As an experienced Molecular Biologist, you will work with machine learning scientists to generate constructs for UTR sequence optimizations.
  • Accelerate mRNA therapeutic development through the generation of 100s of DNA templates to be used for IVT.
  • Work in collaboration with other mRNA scientific and technical experts for optimization of mRNA therapeutics Drug Substance (DS) and Drug Product (DP) processes.

How You Will Achieve It

  • Responsible for developing engineered E.coli cell lines to increase the plasmid quality attributes such as % supercoiling, yield, etc.
  • Design and produce plasmids, gRNAs, and RNPs in a high throughput manner for the screening of various sequence optimizations.
  • Optimize the manner in which cells are cultured, and cell banked.
  • Optimize the plasmid purification processes used in house to arrive at products of the highest quality and purity.
  • Document experimental data in electronic laboratory notebooks (ELNs) in a timely and accurate manner.


  • PhD in biology, biochemistry, molecular biology, cell biology, genetics, bioengineering or a related field with 1+ year experience or BS/MS with 4+ years experience.
  • Hands-on experience with molecular biology techniques including plasmid construction, cloning, and sequence analysis required.
  • Experience building high-throughput, reporter-based bioassays.
  • Knowledge of general machine learning and deep learning models (SVMs, Random Forests, CNNs, RNNs, LSTM etc), in their application to sequences and time series process data is preferred.

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