Senior Research Associate/Associate Scientist, Immunology Drug Discovery

  • Full Time (BS/MS)
  • Full Time (PhD/MD)
  • Boston, MA

Website Jnana Therapeutics

Jnana Therapeutics is a biotechnology company utilizing a next generation chemoproteomic platform to address well-validated but hard-to-drug targets, including the solute carrier (SLC) family of metabolite transporters. Jnana is focused on developing best-in-class therapies to treat a wide range of diseases, including rare genetic and immune-mediated diseases in addition to oncology. Headquartered in Boston, Jnana is founded by world-renowned scientists and backed by leading life science investors.

About the Opportunity

You are an experienced cellular/molecular biologist, a creative and collaborative individual with a strong enthusiasm for experimental research in Immunology.  You have a proven track record operating through ambiguity, and exploration of novel biology though the application of state-of-art molecular biology techniques as well as pharmacological interrogation.  Prior experience working with primary human immune cells is highly desired.  You will employ cutting-edge, high-throughput functional genomics tools, to interrogate novel immune biology and perform mechanistic studies to support the execution of new Drug Discovery programs.  You have experience in translating experimental and novel research findings into a Drug Discovery strategy; an ability to articulate the opportunity against an awareness of unresolved uncertainty, confidence in rationale and therapeutic differentiation for the treatment of severe inflammatory as well as autoimmune diseases.

A strong desire to learn in a growth environment is essential.  Jnana is committed to the training and development of our talent. You will have a track record of being an active team player and exceptional collaborative endeavor as well as excellent communication skills.  You are scientifically curious, treat opportunity and challenges with equal vigor and contribute beyond your precise role description.  This is an outstanding opportunity for a passionate scientist, to build and apply their drug hunting skills while contributing to bringing new classes of medicines to patients.

Responsibilities

  • Routine cell culture (immortalized and primary cell) experience
  • Experience with primary human immune cell isolation, culture, differentiation, and functional assays
  • Development and execution of novel biochemical assays
  • Compound screening to support Med Chem design decisions, experience with liquid handling/robotics
  • Experience with a broad range of measures including reporter gene assays, FACS, ITC/CETSA, HiBit, NanoBRET and MSD/AlphaLISA/ELISA.
  • Performing cellular & molecular biology related protocols: construct design, siRNA/shRNA, CRISPR, RNA extractions, RT-qPCR, Western blotting and imaging.
  • Perform independent data analysis, supporting recommendations on research approach leading to contributing to scientific discussions, meetings, and presentations.

Desired Capabilities & Past Experience

  • Minimum of BSc in Biology, or other relevant area
  • Minimum of 2 years post BSc laboratory research experience, preferably in an immunology setting
  • Relevant knowledge of immunology, appreciation of mechanistic pharmacology and bioassay development.
  • Skilled in biochemical and molecular biology techniques
  • Experience with relevant in vitro immune model systems  to dissect function

To apply for this job please visit boards.greenhouse.io.