Research Associate

  • Full Time (BS/MS)
  • Full Time (PhD/MD)
  • Newton, MA

Stealth-Mode mRNA Engineering Company

We’re a VC/angel-backed, stealth-mode RNA platform company melding new bioE tools, computation, and deep mRNA know-how to establish a systematic method to transform standard of care for neglected diseases.

What You Will Achieve
The mission is to facilitate a best-in-class RNA therapeutic platform that ultimately helps treat or reverse both rare and common diseases that have been completely neglected by biotech/pharma (NOT oncology or infectious diseases) – enable the next 100+ RNA medicines via a differentiated business model and versatile computational bioengineering platform.

How You Will Achieve It
• Work under/with the mRNA Discovery Lead to execute and design experiment plans that enable rapid advancement to IND stage for multiple therapeutic products
• Assist in the development and optimization of the mRNA drug substance platform. This may include performing IVT reactions, mRNA purifications, transient transfections, in process assays.
• Perform routine characterization testing as needed to support product and process development and manufacturing activities.
• Assays include multiple techniques (Luciferase reporter assays, qPCR, Capillary Electrophoresis, etc) used in drug substance and drug product release (identity, integrity, purity) and stability and characterization testing.
• Molecular cloning activities dependent on the candidate’s skillset.

• BA/BS in the life sciences (e.g., Molecular Biology, Biotechnology, or related) with a minimum of 1-2 years related biopharmaceutical experience, or MS with no biopharmaceutical experience.
• Molecular cloning skills (PCR-based or fragment assembly, transformation) is preferred.
• Familiarity with cell-based bioassays and mRNA process or analytical development is a plus.
• Familiarity with lipid nanoparticle formulation, also a plus.
• Drive and desire to accelerate the company objectives within a highly patient- and people-centric company culture.

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