Fermentation Scientist/Engineer

Website LifeMine Therapeutics

Company Description LifeMine Therapeutics, Inc. is the first biotechnology company exploiting the unique ability of fungi to produce powerful drugs optimized through billions of years of evolution, and deploying these molecules for the treatment of intractable human diseases via novel biological mechanisms. The company is using a genome mining and recombinant overexpression approach to mount a massive search for novel drugs through the fungal biosphere. With operations in Cambridge, Massachusetts, Gloucester, Massachusetts, and Basel, Switzerland, LifeMine brings a unique approach to its revolutionary scientific and medical mission.

Job Summary

We are seeking an experienced Fermentation Scientist or Engineer to execute robust and scalable fermentations using filamentous fungi for production of natural products in support of LifeMine’s genomically-enabled drug discovery platform.

 Job Responsibilities

  • Plan and conduct filamentous fungal fermentations using bioreactors at multiple scales
  • Establish and optimize seed train for various wild-type and genetically engineered fungal strains targeted for large-scale fermentation production
  • Identify and implement fermentation productivity improvements, scientific and engineering principles, as well as statistical process design and analysis
  • Apply current industry best practices, proactively evaluate new technologies, stay current with relevant literature, and implement new features and functionality in the bioprocess development platform
  • Engage in close, cross-functional collaborations with LifeMine’s Genomics, Strain Engineering, Microbiology, Natural Product Chemistry, and Bioinformatics groups to interpret data, reach conclusions, and make decisions
  • Ensure safe and axenic operation of all fermentation equipment

 Job Requirements

  • MS or PhD in chemical engineering or related field with 2+ years of experience in fermentation process development using microbes
  • Microbial fermentation expertise with bioreactors at multiple scales using non-conventional microbes.  Filamentous fungal experience highly preferred
  • Knowledge of and hands-on experience with fermentation process design, optimization (DOE), and mixing/mass transfer
  • Working experience with statistical process design and analysis such as JMP and SpotFire
  • Ability to identify complex problems, review data to determine root cause, evaluate options and implement solutions
  • Demonstrated ability to work independently as well as in team environment, multitask and ensure flexibility in a dynamic environment required
  • Ability to lift 50 pounds
  • Ability to travel between our Gloucester and Cambridge locations
  • An understanding of Six Sigma and lean manufacturing principles preferred

To apply for this job please visit lifeminetx.com.