At Biogen, our mission is clear: we are pioneers in neuroscience. Since our founding in 1978 as one of the world’s first global biotechnology companies, Biogen has led innovative scientific research with the goal over the last decade to defeat devastating neurological diseases.
Spatial transcriptomics is a new technology to perform mRNA expression profiling of a tissue while also providing spatial information of the gene expression activity. This spatial gene expression information can yield new insights into disease pathology, gene expression in distinct biological compartments, expression profiles in rare cell populations, and expression profiling along contours. Specifically, Biogen is interested in spatial transcriptomics to understand lesion development and expansion in multiple sclerosis (MS).
Analytics and Data Sciences in conjunction with Translational Biology will co-lead the internship project. The intern will focus on improving Biogen’s current analysis pipeline for spatial gene expression profiling by reading associated literature, developing exploratory simulations to compare analysis approaches, and finally implementing the analysis pipeline as an R package. If time permits, the intern will work on integration of single nuclei RNAseq (snRNAseq) and spatial transcriptomics data for mouse models as well as human brain MS lesions.
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