Associate Scientist/Scientist I, High Throughput Screening and Automation

  • Full Time (BS/MS)
  • Full Time (PhD/MD)
  • Boston, MA

Website Jnana Therapeutics

Jnana Therapeutics is a biotechnology company utilizing a next generation chemoproteomic platform to address well-validated but hard-to-drug targets, including the solute carrier (SLC) family of metabolite transporters. Jnana is focused on developing best-in-class therapies to treat a wide range of diseases, including rare genetic and immune-mediated diseases in addition to oncology. Headquartered in Boston, Jnana is founded by world-renowned scientists and backed by leading life science investors.

About the Opportunity

Jnana is seeking a talented and adaptable (Associate) Scientist to join the Hit Generation team within the Chemical Biology group. The Hit Generation team is responsible for running high-throughput screens that leverage Jnana’s RAPID platform to identify small molecules binders for a range of historically hard-to-drug targets, including transcription factors, helicases, scaffolding proteins, and solute carriers (SLCs).

RAPID is a next generation chemoproteomic platform that enables the chemical mapping of druggable sites on any target protein inside of a living cell. Once we’ve identified a chemical probe for a druggable site of interest, you and your team will screen our in-house chemical libraries for lead-like small molecules that can bind to the same site in a live cell.

The ideal candidate has a demonstrated track record of employing a range of modern laboratory automation equipment (Tecans, Bioteks, Echo, etc.) to execute cell-based assays in high throughput formats (384 & 1536). In addition to the planning and execution of experiments, the candidate will also aid in data analysis/interpretation, and present key findings to project teams.  The candidate will work in a dynamic, fast-paced environment where they will join a collaborative multi-disciplinary team generating key data impacting the entire organization.

A strong desire to learn in a growth environment is essential.  Jnana is committed to the training and development of our talent. You will have a track record of team working and exceptional collaborative endeavor as well as excellent communication skills.  You are scientifically curious, treat opportunity and challenges with equal vigor and contribute beyond your precise role description.  This is an outstanding opportunity for a passionate scientist, to apply their skills while contributing to bringing new classes of medicines to patients.

Responsibilities

  • Work on the RAPID team to run Jnana’s proprietary cell-based hit generation engine, RAPID.
  • Operate, optimize, and maintain a variety of liquid handling instrumentation (Tecans, Biotek, Echo, etc.).  This includes building and programming new methods.
  • Troubleshoot experimental design and assay optimization.
  • Analyze experimental data and present results at project meetings.

Desired Capabilities & Past Experience

  • Ph.D. with 2+ years relevant experience; B.S./M.S. 5+ years relevant industry experience
  • Proficient with operating, programming, and optimizing various instrumentation enabling HTS including Tecan Evo, Biotek EL406, and Labcyte Echo.
  • Experience in cell-based high-throughput screening
  • Excellent communication and organizational skills
  • Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines
  • Experience in computational methods and/or coding is a plus
  • Maintain a safe and productive laboratory environment.

To apply for this job please visit boards.greenhouse.io.